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VIP (Vasoactive Intestinal Peptide) is a widely distributed neuropeptide that functions as a neuromodulator and neurotransmitter. It is extensively researched for its influence on the Gut-Brain-Immune axis, specifically for its ability to bind to Class II G-protein-coupled receptors (VPAC1 and VPAC2).
Researchers frequently utilize VIP to investigate immune system modulation (specifically T-regulatory cell function), circadian rhythm entrainment, and pulmonary vascular health.
A Master Regulator of Immune and Neuroendocrine Function
Vasoactive Intestinal Peptide (VIP) is a naturally occurring peptide hormone found in the intestine, pancreas, and suprachiasmatic nuclei of the hypothalamus. In the laboratory, synthetic VIP is a critical tool for studying immunomodulation and systemic inflammation.
Unlike peptides that target a single pathway, VIP is observed to exhibit pleiotropic effects—meaning it influences multiple systems simultaneously. By activating the VPAC1 and VPAC2 receptors, VIP triggers the cAMP signaling cascade, which downstream research suggests may:
Modulate Cytokine Profiles: Shift immune responses from a pro-inflammatory (Th1) state to an anti-inflammatory (Th2/Treg) state.
Regulate Circadian Rhythm: VIP is highly concentrated in the brain's "master clock" (SCN), where it helps synchronize biological rhythms.
Support Mucosal Immunity: It plays a vital role in maintaining the integrity of the gut barrier and regulating gastric motility.
At Pepformance.com, our VIP is synthesized to the highest purity standards to ensure consistent, repeatable data in your experimental models.
Immune Tolerance: Research indicates VIP may suppress the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-12) while promoting the activity of Regulatory T Cells (Tregs). This mechanism is currently under review in models of autoimmune disorders and Chronic Inflammatory Response Syndrome (CIRS).
Vasodilation: VIP is a potent vasodilator, particularly in the pulmonary and splanchnic circulation, leading to its study in models of Pulmonary Arterial Hypertension (PAH).
CIRS & Biotoxin Illness Models: Investigating the correlation between low VIP levels and chronic inflammation caused by environmental exposures (e.g., mold/mycotoxins).
Autoimmune Encephalomyelitis: Studying the neuroprotective effects of VIP in preventing demyelination.
Gut Motility & IBD: Assessing the peptide's ability to reduce inflammation in colitis models and restore proper intestinal contractions.
Fibrosis Studies: Researching the inhibition of tissue remodeling and fibrosis in heart and lung tissue.
FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.
This product is sold by Pepformance.com explicitly for laboratory research, analysis, and scientific study. It is not a drug, food, or cosmetic product.
Not for human use: This product is not FDA-approved for the treatment of any medical condition (such as CIRS, Lyme, or IBS).
Handling: Should only be handled by qualified professionals equipped with appropriate laboratory safety gear.
Ingestion: Any mention of personal use or human consumption will result in the immediate cancellation of your order and blacklisting from our site.