Out of stock
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a potent 16-amino acid peptide encoded within the mitochondrial genome. As a signaling member of the Mitochondrial-Derived Peptide (MDP) family, MOTS-c plays a critical role in mitochondrial-nuclear communication, translocating to the nucleus in response to metabolic stress to regulate nuclear gene expression and maintain cellular homeostasis.
AMPK Pathway Activation: Investigates the peptide's role in triggering AMP-activated protein kinase, a master regulator of energy metabolism.
Mitochondrial Biogenesis: Research focusing on the upregulation of PGC-1α to study the formation of new mitochondria.
Insulin Sensitivity Studies: Exploration of the folate-AICAR-AMPK axis and its impact on glucose uptake in cellular models.
Exercise Mimicry: Used to study the molecular signaling pathways typically associated with physical exertion.
Cellular Longevity: Scientific inquiry into the age-dependent decline of endogenous MDP levels.
MOTS-c functions by modulating the folate cycle and de novo purine synthesis. This process leads to an accumulation of AICAR, which triggers the phosphorylation of AMPK. In laboratory settings, researchers observe how this cascade promotes GLUT4 translocation, facilitating glucose disposal and fatty acid oxidation.
Sequence:
Molecular Formula:
Molecular Weight: 2174.62 g/mol
Purity: ≥98% (HPLC/MS Verified)
Format: Lyophilized white powder
Storage: Store at -20°C for long-term stability. Protect from light.
FOR LABORATORY RESEARCH USE ONLY. This product is a synthetic laboratory reagent intended strictly for in vitro and animal model research. It is not for human or veterinary use. MOTS-c is not a medication, food, or dietary supplement. The purchaser assumes all responsibility for the handling and use of this compound in a controlled, professional environment.